EMBRYONIC
STEM CELLS, just
as their name suggests, are derived from
microscopic,
5 – 7 day-old embryos. Rather than being a heart, muscle,
brain
or
other specific cell type, these primitive cells contain all the
information that is
needed
to create any cell type of the human body—a quality that
scientists call
pluripotency. The
ability to turn into any cell types makes these cells the most
sought-after
by scientists. Other qualities that make embryonic stem
cells
valuable
is that they are highly energetic, can multiply themselves
in great
numbers,
and do not suffer from any of the genetic “wear and tear” of
adult cells.
It
is hoped that embryonic stem cells will eventually be used to
generate a huge
number
of different replacement cells for people suffering from a large
array of
diseases,
injuries and birth defects.
ADULT
STEM CELLS are found
in various organs of the fully developed human
body.
These cells are slightly more differentiated than embryonic stem
cells,
meaning
that they can give rise to a limited number of other cell
types. For
example, a
neural stem cell can produce neurons and several other nerve
cell
types,
but it cannot give rise to blood or bone cells. Scientists continue
to
discover
adult stem cells in different parts of the body, but it
is believed that
some
organs may not produce adult stem cells at all. Another limitation
of adult
stem
cells is that they are hard to isolate and to grow in lab dishes,
meaning that
it
is difficult to produce the large numbers of cells that are needed
for a cellular
transplant.
Adult cells can also exhibit some genetic damage, which would
make
them
more vulnerable to age-related diseases such as cancer.
UMBILICAL
CORD BLOOD is
a recently discovered source of stem cells. But
contrary
to what many people believe, the stem cells in umbilical cord
blood are
not
embryonic stem cells—they are considered to be adult stem
cells. Although
some
recent studies have suggested that these cells can be influenced
to behave
in
more flexible ways than other adult stem cells, this research
has yet to be
confirmed.
What is known about umbilical cord blood cells is that they have
a
similar
capacity to the stem cells found in bone marrow, and can give
rise to
several
different cell types.
FETAL
GERM CELLS harbor stem cells
that are highly versatile,
but it is not known
for
sure whether these cells artruly pluripotent. These cells are
found in early-stage
fetusesof
about 4 – 6 weeks of development, after the termination
or miscarriage
of
a pregnancy. These cells are useful for experimentation, but
they have not
proven
to be as versatile as embryonic cells. Scientists can gain access
to the
tissue
that houses these cells through universities and tissue banks
after the
decision
has been made to terminate a pregnancy and the tissue has been
donated
for
research.
"The
very best scientists in the world, the most responsible scientists
in the world, are
in
favor of embryonic stem cell research. They feel that this
is the dawning of a new
era
of better understanding about the mechanisms of disease,
about drug development
to
treat disease, and most interestingly, about the possibility
of restorative therapy, of replacing cells that have degenerated.
This is different from symptomatic therapy, and
if
it’s true, it can cause a revolution in medicine that
will have implications worldwide."
- Gerald Fischbach,
Dean of the Faculty of Medicine,
Columbia University
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Over
128 million Americans are prisoners of their own bodies, living
with diseases that may potentially be treated with stem cells.
• The
number one killer in America is Heart Disease, followed by
Cancer as the leading cause of death in the United States.
HIV/AIDS trails closely behind.
• Every 34 seconds
a person in the U.S. dies from cardiovascular complications.
• Approximately
14,000 people contract HIV every day.
• This
year alone 570,280 Americans will die from cancer. Heart attacks,
chemotherapy and deterioration of one’s body come with
the territory.
• Spinal Muscular Atrophy,
a not so known neuromuscular condition, is the top genetic killer
of children under the age of two. Children can't roll, walk,
turn, eat or drink but have brilliant minds.1 in every 40 people
carry this gene, while 1 in every 6,000 children are born with
SMA.
• Diabetes, Parkinson’s,
Alzheimer’s, Sickle Cell Anemia and Lupus are a variety
of painful diseases that millions of Americans deal with on a
daily basis. Sustained by doctor visits and ongoing doses of
medications and injections to keep those diagnosed alive, for
some it’s manageable, for others it’s a slow death
that eventually gets the best of you.
• Over 18 million people
in the U.S. have diabetes, over 1 million have Parkinson’s,
4.5 million have Alzheimer’s, 72,000 are affected by Sickle
Cell Anemia and 1.5 million have Lupus.
• For those afflicted
with Spinal Cord Injuries, Multiple Sclerosis and Lou Gehrig's
disease (ALS), paralysis is not just another word in the dictionary.
Numbness, blindness and loss of control over one’s body
becomes a way of life. Walking becomes something you observe
from a wheelchair. Every year approximately 11,000 new spinal
cord injuries are reported. An estimated 400,000 Americans have
MS, while approximately 30,000 people in the United States have
the fatal neuromuscular disease named after sports legend Lou
Gehrig. These disorders attack the central nervous system and
they attack them hard.
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